Research Output 1974 2017

2017
2 Citations

Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88

Blednov, Y. A., Black, M., Chernis, J., Da Costa, A., Mayfield, J. & Harris, R. A. 2017 In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Drinking
Ethanol
Bottles
Knockout Mice
Saccharin
2 Citations

Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents

Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F., Roberts, A. J., Roberts, E., George, O., Mayfield, J., Billiar, T. R., Hackam, D. J., Mayfield, R. D., Koob, G. F., Roberto, M. & Homanics, G. E. Feb 1 2017 In : Journal of Neuroscience. 37, 5, p. 1139-1155 17 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Rodentia
Ethanol
Drinking
gamma-Aminobutyric Acid
1 Citations

Mechanistic insights into epigenetic modulation of ethanol consumption

Ponomarev, I., Stelly, C. E., Morikawa, H., Blednov, Y. A., Mayfield, R. D. & Harris, R. A. May 1 2017 In : Alcohol. 60, p. 95-101 7 p.

Research output: Contribution to journalArticle

consumption
Epigenomics
Ethanol
area
Ventral Tegmental Area

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination

Blednov, Y. A., Borghese, C. M., Ruiz, C. I., Cullins, M. A., Da Costa, A., Osterndorff-Kahanek, E. A., Homanics, G. E. & Harris, R. A. Sep 1 2017 In : Neuropharmacology. 123, p. 201-209 9 p.

Research output: Contribution to journalArticle

Ataxia
gamma-Aminobutyric Acid
Ethanol
Mutation
Alcoholism
1 Citations

Sedative and Motor Incoordination Effects of Ethanol in Mice Lacking CD14, TLR2, TLR4, or MyD88

Blednov, Y. A., Black, M., Benavidez, J. M., Da Costa, A., Mayfield, J. & Harris, R. A. 2017 In : Alcoholism: Clinical and Experimental Research.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Ataxia
Hypnotics and Sedatives
Ethanol
Muscle Contraction

The future is now: A 2020 view of alcoholism research

Harris, R. A. & Koob, G. F. Aug 1 2017 In : Neuropharmacology. 122, p. 1-2 2 p.

Research output: Contribution to journalEditorial

The Neuroimmune Basis of Excessive Alcohol Consumption

Mayfield, J. & Harris, R. A. Jan 1 2017 In : Neuropsychopharmacology. 42, 1, p. 376-377 2 p.

Research output: Contribution to journalComment/debate

Alcohol Drinking
2016
3 Citations

Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons

Marballi, K., Genabai, N. K., Blednov, Y. A., Harris, R. A. & Ponomarev, I. Mar 1 2016 In : Genes, Brain and Behavior. 15, 3, p. 318-326 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Dopaminergic Neurons
Alcohol Drinking
Alcohols
Gene Expression
2 Citations

DNA modifications in models of alcohol use disorders

Tulisiak, C. T., Harris, R. A. & Ponomarev, I. Sep 2 2016 In : Alcohol.

Research output: Contribution to journalArticle

Alcohols
DNA
alcohol
Methylation
modification
2 Citations

FMRP regulates an ethanol-dependent shift in GABA B R function and expression with rapid antidepressant properties

Wolfe, S. A., Workman, E. R., Heaney, C. F., Niere, F., Namjoshi, S., Cacheaux, L. P., Farris, S. P., Drew, M. R., Zemelman, B. V., Harris, R. A. & Raab-Graham, K. F. Sep 26 2016 In : Nature Communications. 7, 12867

Research output: Contribution to journalArticle

Fragile X Mental Retardation Protein
gamma-Aminobutyric Acid
Antidepressive Agents
Ethanol
ethyl alcohol
4 Citations

Genes and Alcohol Consumption: Studies with Mutant Mice

Mayfield, J., Arends, M. A., Harris, R. A. & Blednov, Y. A. 2016 In : International Review of Neurobiology. 126, p. 293-355 63 p.

Research output: Contribution to journalArticle

Alcohol Drinking
Drinking
Genes
Alcohols
Self Administration
5 Citations

Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors

Borghese, C. M., Ruiz, C. I., Lee, U. S., Cullins, M. A., Bertaccini, E. J., Trudell, J. R. & Harris, R. A. Jan 20 2016 In : ACS Chemical Neuroscience. 7, 1, p. 100-108 9 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Binding Sites
Alcohols
Mutation
Hexanols
1 Citations

Inter- and intra-subunit butanol/isoflurane sites of action in the human glycine receptor

McCracken, M. L., Gorini, G., McCracken, L. M., Dayne Mayfield, R., Harris, R. A. & Trudell, J. R. Jun 14 2016 In : Frontiers in Molecular Neuroscience. 9, JUNE, 45

Research output: Contribution to journalArticle

Glycine Receptors
Butanols
Isoflurane
Anesthetics
Alcohols
2 Citations

Localization of PPAR isotypes in the adult mouse and human brain

Warden, A., Truitt, J., Merriman, M., Ponomareva, O., Jameson, K., Ferguson, L. B., Mayfield, R. D. & Harris, R. A. Jun 10 2016 In : Scientific Reports. 6, 27618

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Brain
Messenger RNA
Proteins
Ventral Tegmental Area
5 Citations

PPAR Agonists: II. Fenofibrate and Tesaglitazar Alter Behaviors Related to Voluntary Alcohol Consumption

Blednov, Y. A., Black, M., Benavidez, J. M., Stamatakis, E. E. & Harris, R. A. Mar 1 2016 In : Alcoholism: Clinical and Experimental Research. 40, 3, p. 563-571 9 p.

Research output: Contribution to journalArticle

Fenofibrate
Peroxisome Proliferator-Activated Receptors
Alcohol Drinking
Startle Reflex
Saccharin
6 Citations

PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice

Blednov, Y. A., Black, M., Benavidez, J. M., Stamatakis, E. E. & Harris, R. A. Mar 1 2016 In : Alcoholism: Clinical and Experimental Research. 40, 3, p. 553-562 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Alcohol Drinking
Fenofibrate
Bottles
Drinking
6 Citations

Synaptic micrornas coordinately regulate synaptic mRnas: Perturbation by chronic alcohol consumption

Most, D., Leiter, C., Blednov, Y. A., Harris, R. A. & Mayfield, R. D. Jan 1 2016 In : Neuropsychopharmacology. 41, 2, p. 538-548 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Alcohol Drinking
Alcohols
Messenger RNA
Transcriptome
2 Citations

The neuroimmune transcriptome and alcohol dependence: Potential for targeted therapies

Warden, A., Erickson, E., Robinson, G., Harris, R. A. & Mayfield, R. D. Dec 1 2016 In : Pharmacogenomics. 17, 18, p. 2081-2096 16 p.

Research output: Contribution to journalReview article

Transcriptome
Alcoholism
Brain
Gene Regulatory Networks
Toll-Like Receptors
2015
6 Citations

Applying the new genomics to alcohol dependence

Farris, S. P., Pietrzykowski, A. Z., Miles, M. F., O'Brien, M. A., Sanna, P. P., Zakhari, S., Mayfield, R. D. & Harris, R. A. Dec 1 2015 In : Alcohol. 49, 8, p. 825-836 12 p.

Research output: Contribution to journalArticle

Genomics
Alcoholism
Alcohols
alcohol
Gene Regulatory Networks
8 Citations

Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction

Mayfield, J., Blednov, Y. A. & Harris, R. A. 2015 International Review of Neurobiology - Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels, 2015. Academic Press Inc., Vol. 123, p. 279-313 35 p. (International Review of Neurobiology; vol. 123)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Behavioral Genetics
Substance-Related Disorders
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Central Nervous System Diseases
Genetic Association Studies
12 Citations

Brain pathways to recovery from alcohol dependence

Cui, C. , Noronha, A. , Warren, K. R. , Koob, G. F. , Sinha, R. , Thakkar, M. , Matochik, J. , Crews, F. T. , Chandler, L. J. , Pfefferbaum, A. , Becker, H. C. , Lovinger, D. , Everitt, B. J. , Egli, M. , Mandyam, C. D. , Fein, G. , Potenza, M. N. , Harris, R. A. , Grant, K. A. , Roberto, M. & 2 others Meyerhoff, D. J. & Sullivan, E. V. Aug 1 2015 In : Alcohol. 49, 5, p. 435-452 18 p.

Research output: Contribution to journalArticle

alcohol
Alcoholism
Brain
Muscle Contraction
brain
15 Citations

Chronic ethanol exposure produces timeand brain region-dependent changes in gene coexpression networks

Osterndorff-Kahanek, E. A., Becker, H. C., Lopez, M. F., Farris, S. P., Tiwari, G. R., Nunez, Y. O., Harris, R. A. & Mayfield, R. D. Mar 24 2015 In : PLoS ONE. 10, 3, e0121522

Research output: Contribution to journalArticle

Gene Regulatory Networks
Ethanol
Brain
Genes
genes
8 Citations

Epigenetic modulation of brain gene networks for cocaine and alcohol abuse

Farris, S. P., Harris, R. A. & Ponomarev, I. 2015 In : Frontiers in Neuroscience. 9, APR, 176

Research output: Contribution to journalArticle

Cocaine-Related Disorders
Gene Regulatory Networks
Epigenomics
Alcoholism
Gene Expression
2 Citations

Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors

Horani, S., Stater, E. P., Corringer, P. J., Trudell, J. R., Harris, R. A. & Howard, R. J. Jun 1 2015 In : Alcoholism: Clinical and Experimental Research. 39, 6, p. 962-968 7 p.

Research output: Contribution to journalArticle

Ligand-Gated Ion Channels
Glycine Receptors
Ethanol
Cysteine Loop Ligand-Gated Ion Channel Receptors
Ion Channels
11 Citations

Glycine receptors containing α2 or α3 subunits regulate specific ethanol-mediated behaviors

Blednov, Y. A., Benavidez, J. M., Black, M., Leiter, C. R., Osterndorff-Kahanek, E. & Harris, R. A. 2015 In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 181-191 11 p.

Research output: Contribution to journalArticle

Glycine Receptors
Ethanol
Righting Reflex
Knockout Mice
Genes
21 Citations

Peroxisome Proliferator-Activated Receptors α and γ are Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

Blednov, Y. A., Benavidez, J. M., Black, M., Ferguson, L. B., Schoenhard, G. L., Goate, A. M., Edenberg, H. J., Wetherill, L., Hesselbrock, V., Foroud, T. & Adron Harris, R. Jan 1 2015 In : Alcoholism: Clinical and Experimental Research. 39, 1, p. 136-145 10 p.

Research output: Contribution to journalArticle

PPAR alpha
Peroxisome Proliferator-Activated Receptors
PPAR gamma
Alcohol Drinking
Alcoholism
5 Citations

Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines

Blednov, Y. A., Benavidez, J. M., Black, M., Mayfield, J. & Harris, R. A. Aug 1 2015 In : Neuropharmacology. 95, p. 309-320 12 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Benzodiazepines
Ethanol
Hypnotics and Sedatives
Flurazepam
9 Citations

Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala

Bajo, M., Herman, M. A., Varodayan, F. P., Oleata, C. S., Madamba, S. G., Harris, R. A., Blednov, Y. A. & Roberto, M. Mar 1 2015 In : Brain, Behavior, and Immunity. 45, p. 189-197 9 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Ethanol
Central Amygdaloid Nucleus
gamma-Aminobutyric Acid
Inhibitory Postsynaptic Potentials
14 Citations

Transcriptome organization for chronic alcohol abuse in human brain

Farris, S. P., Arasappan, D., Hunicke-Smith, S., Harris, R. A. & Mayfield, R. D. Nov 1 2015 In : Molecular Psychiatry. 20, 11, p. 1438-1447 10 p.

Research output: Contribution to journalArticle

Transcriptome
Alcohol Drinking
Alcoholism
Brain
Alcohols
2014
1 Citations

Alcohol and the Brain: An Epigenetic Viewpoint

Marballi, K., Ponomarev, I., Mayfield, R. D. & Harris, R. A. Feb 2014 Neurobiology of Alcohol Dependence. Elsevier Inc., p. 349-358 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Alcoholism
Alcohols
Brain
Gene Expression
31 Citations

Alcohol dependence: Molecular and behavioral evidence

Trudell, J. R., Messing, R. O., Mayfield, J. & Harris, R. A. 2014 In : Trends in Pharmacological Sciences. 35, 7, p. 317-323 7 p.

Research output: Contribution to journalReview article

Alcoholism
Alcohols
Proteins
Ion Channels
Cyclic AMP Receptor Protein
5 Citations

Altered gamma-aminobutyric acid type B receptor subunit 1 splicing in alcoholics

Lee, C., Mayfield, R. D. & Harris, R. A. May 15 2014 In : Biological Psychiatry. 75, 10, p. 765-773 9 p.

Research output: Contribution to journalArticle

Alcoholics
gamma-Aminobutyric Acid
Exons
Alcohols
Genes
19 Citations

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.

Blednov, Y. A., Benavidez, J. M., Black, M., Leiter, C. R., Osterndorff-Kahanek, E., Johnson, D., Borghese, C. M., Hanrahan, J. R., Johnston, G. A. R., Chebib, M. & Harris, R. A. 2014 In : PloS one. 9, 1

Research output: Contribution to journalArticle

ethanol
GABA(A) Receptor
Ethanol
mice
receptors
14 Citations

GABAA receptor transmembrane amino acids are critical for alcohol action: Disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

Borghese, C. M., Hicks, J. A., Lapid, D. J., Trudell, J. R. & Harris, R. A. Feb 1 2014 In : Journal of Neurochemistry. 128, 3, p. 363-375 13 p.

Research output: Contribution to journalArticle

Amino Acid Receptors
Disulfides
gamma-Aminobutyric Acid
Cysteine
Binding Sites
13 Citations

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Blednov, Y. A., Benavidez, J. M., Black, M. & Adron Harris, R. 2014 In : Frontiers in Neuroscience. 8 MAY, 129

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Inbred C57BL Mouse
Ethanol
Inhibition (Psychology)
Rolipram
18 Citations

Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala

Bajo, M., Madamba, S. G., Roberto, M., Blednov, Y. A., Sagi, V. N., Roberts, E., Rice, K. C., Harris, R. A. & Siggins, G. R. 2014 In : Brain, Behavior, and Immunity. 40, p. 191-202 12 p.

Research output: Contribution to journalArticle

Immunologic Factors
Ethanol
Central Amygdaloid Nucleus
Inhibitory Postsynaptic Potentials
Lipopolysaccharides
7 Citations

Molecular basis of alcoholism

Most, D., Ferguson, L. & Harris, R. A. 2014 In : Handbook of Clinical Neurology. 125, p. 89-111 23 p.

Research output: Contribution to journalArticle

Alcoholism
Alcohols
Gene Expression
Brain
Addictive Behavior
10 Citations

Neurobiology of Alcohol Dependence

Noronha, A., Cui, C., Harris, R. A. & Crabbe, J. C. Feb 2014 Elsevier Inc.560 p.

Research output: Book/ReportBook

Neurobiology
Alcoholism
Neural Pathways
Neuronal Plasticity
Foster Home Care
14 Citations

Neuroimmune mechanisms of alcohol and drug addiction

Cui, C., Shurtleff, D. & Harris, R. A. 2014 In : International Review of Neurobiology. 118, p. 1-12 12 p.

Research output: Contribution to journalArticle

Neuroimmunomodulation
Street Drugs
Alcoholism
Substance-Related Disorders
Alcohols
19 Citations

Neuroimmune pathways in alcohol consumption: Evidence from behavioral and genetic studies in rodents and humans

Robinson, G., Most, D., Ferguson, L. B., Mayfield, J., Harris, R. A. & Blednov, Y. A. 2014 In : International Review of Neurobiology. 118, p. 81-109 29 p.

Research output: Contribution to journalArticle

Behavioral Genetics
Alcohol Drinking
Rodentia
Alcohols
Ethanol
22 Citations

PPAR agonists regulate brain gene expression: Relationship to their effects on ethanol consumption

Ferguson, L. B., Most, D., Blednov, Y. A. & Harris, R. A. 2014 In : Neuropharmacology. 86, p. 397-407 11 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Ethanol
Gene Expression
Brain
Bezafibrate
17 Citations

Proteomic approaches and identification of novel therapeutic targets for alcoholism

Gorini, G., Adron Harris, R. & Dayne Mayfield, R. Jan 2014 In : Neuropsychopharmacology. 39, 1, p. 104-130 27 p.

Research output: Contribution to journalReview article

Proteomics
Alcoholism
Proteins
Alcohols
Proteome
21 Citations

Seeking structural specificity: Direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics

Howard, R. J., Trudell, J. R. & Adron Harris, R. Apr 2014 In : Pharmacological Reviews. 66, 2, p. 396-412 17 p.

Research output: Contribution to journalReview article

Ligand-Gated Ion Channels
General Anesthetics
Anesthetics
Alcohols
Behavior Therapy
10 Citations

Synaptic adaptations by alcohol and drugs of abuse: Changes in microRNA expression and mRNA regulation

Most, D., Workman, E. & Adron Harris, R. Dec 16 2014 In : Frontiers in Molecular Neuroscience. 7, DEC, 85

Research output: Contribution to journalArticle

Street Drugs
MicroRNAs
Alcoholism
Messenger RNA
Protein Biosynthesis
7 Citations

The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol

Most, D., Ferguson, L., Blednov, Y., Mayfield, R. D. & Harris, R. A. Aug 19 2014 In : Pharmacogenomics Journal.

Research output: Contribution to journalArticle

Transcriptome
Alcohols
Gene Expression
Amygdala
Alcohol Drinking
2013
4 Citations

Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice

Ozburn, A. R., Harris, R. A. & Blednov, Y. A. Mar 2013 In : Pharmacology Biochemistry and Behavior. 104, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Hypnotics and Sedatives
Alcohol Drinking
Ethanol
Alcohols
Human Engineering
6 Citations

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels

Heusser, S. A., Howard, R. J., Borghese, C. M., Cullins, M. A., Broemstrup, T., Lee, U. S., Lindahl, E., Carlsson, J. & Harris, R. Nov 2013 In : Molecular Pharmacology. 84, 5, p. 670-678 9 p.

Research output: Contribution to journalArticle

Ligand-Gated Ion Channels
General Anesthetics
Propofol
gamma-Aminobutyric Acid
GABA(A) Receptor
29 Citations

Gene Expression in Brain and Liver Produced by Three Different Regimens of Alcohol Consumption in Mice: Comparison with Immune Activation

Osterndorff-Kahanek, E., Ponomarev, I., Blednov, Y. A. & Harris, R. A. Mar 29 2013 In : PLoS ONE. 8, 3, e59870

Research output: Contribution to journalArticle

Alcohol Drinking
Lipopolysaccharides
Gene Expression
Liver
Brain
16 Citations

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites

Brömstrup, T., Howard, R. J., Trudell, J. R., Harris, R. A. & Lindahl, E. Aug 6 2013 In : Structure. 21, 8, p. 1307-1316 10 p.

Research output: Contribution to journalArticle

Ligand-Gated Ion Channels
Chloroform
Anesthetics
Ligands
Mutation
17 Citations

Linking GABAA receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication

Blednov, Y. A., Benavidez, J. M., Black, M., Chandra, D., Homanics, G. E., Rudolph, U. & Harris, R. A. Apr 2013 In : Neuropharmacology. 67, p. 46-56 11 p.

Research output: Contribution to journalArticle

Alcoholic Intoxication
gamma-Aminobutyric Acid
Ethanol
Alcohols
Ataxia