Advanced architectures in the design of responsive polymers for cancer nanomedicine

Angela M. Wagner, David S. Spencer, Nicholas Peppas

Research output: Contribution to journalReview article

  • 1 Citations

Abstract

In recent decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. As such, the desire to engineer dynamic and functional materials is becoming more prevalent in an effort to achieve precise control over our environment. The combination of controlled radical polymerization and high yielding chemistry strategies provide an excellent basis for the development of the next generation of drug delivery systems. The versatility of polymer chemistries available enables the synthesis of increasingly complex architectures with enhanced delivery specificity and control over the desired properties to interface with biological systems. This tutorial review highlights recent developments in polymer-based approaches to internally responsive nanoparticles for oncology. Presented are concise overviews of the current challenges and opportunities in cancer nanomedicine, common polymer-based architectures, and the basis for internally triggered stimuli–response relationships commonly employed in oncology applications. Examples of the chemistry used in the design of environmentally labile nanomaterials are discussed, and we outline recent advances in creating advanced bioresponsive drug delivery architectures.

LanguageEnglish (US)
Article number46154
JournalJournal of Applied Polymer Science
Volume135
Issue number24
DOIs
StatePublished - Jun 20 2018

Fingerprint

Medical nanotechnology
Oncology
Polymers
Nanoparticles
Functional materials
Biological systems
Free radical polymerization
Drug delivery
Nanostructured materials
Engineers

Keywords

  • biomaterials
  • biomedical applications
  • drug delivery systems
  • nanostructured polymers
  • stimuli-sensitive polymers

ASJC Scopus subject areas

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Advanced architectures in the design of responsive polymers for cancer nanomedicine. / Wagner, Angela M.; Spencer, David S.; Peppas, Nicholas.

In: Journal of Applied Polymer Science, Vol. 135, No. 24, 46154, 20.06.2018.

Research output: Contribution to journalReview article

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