Advances in asthma in 2017: Mechanisms, biologics, and genetics

Mitchell H. Grayson, Scott Feldman, Benjamin T. Prince, Priya J. Patel, Elizabeth Matsui, Andrea J. Apter

Research output: Contribution to journalArticle

Abstract

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. Finally, we conclude with a discussion of advances in health literacy and how they will affect asthma care.

LanguageEnglish (US)
Pages1423-1436
Number of pages14
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number5
DOIs
StatePublished - Nov 1 2018

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Biological Products
Asthma
Health Literacy
Genetic Heterogeneity
Biomarkers
Phenotype
Research

Keywords

  • airway hyperreactivity
  • allergens
  • Asthma
  • asthma biomarkers
  • asthma phenotypes
  • B cells
  • biologic therapies
  • environment
  • eosinophils
  • genetics
  • helper T cells
  • innate lymphoid cells
  • microbiome
  • neutrophils
  • respiratory viruses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Grayson, M. H., Feldman, S., Prince, B. T., Patel, P. J., Matsui, E., & Apter, A. J. (2018). Advances in asthma in 2017: Mechanisms, biologics, and genetics. Journal of Allergy and Clinical Immunology, 142(5), 1423-1436. https://doi.org/10.1016/j.jaci.2018.08.033

Advances in asthma in 2017 : Mechanisms, biologics, and genetics. / Grayson, Mitchell H.; Feldman, Scott; Prince, Benjamin T.; Patel, Priya J.; Matsui, Elizabeth; Apter, Andrea J.

In: Journal of Allergy and Clinical Immunology, Vol. 142, No. 5, 01.11.2018, p. 1423-1436.

Research output: Contribution to journalArticle

Grayson, MH, Feldman, S, Prince, BT, Patel, PJ, Matsui, E & Apter, AJ 2018, 'Advances in asthma in 2017: Mechanisms, biologics, and genetics' Journal of Allergy and Clinical Immunology, vol. 142, no. 5, pp. 1423-1436. https://doi.org/10.1016/j.jaci.2018.08.033
Grayson, Mitchell H. ; Feldman, Scott ; Prince, Benjamin T. ; Patel, Priya J. ; Matsui, Elizabeth ; Apter, Andrea J. / Advances in asthma in 2017 : Mechanisms, biologics, and genetics. In: Journal of Allergy and Clinical Immunology. 2018 ; Vol. 142, No. 5. pp. 1423-1436.
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