An assessment of the performance of the baxter elastomeric (LV10) infusor™ pump under hyperbaric conditions

Stephen Perks, Denise F. Blake, Derelle A. Young, John Hardman, Lawrence H. Brown, Iestyn Lewis, Tilley Pain

Research output: Research - peer-reviewArticle

Abstract

Introduction: There are limited data on the use of elastomeric infusion pumps during hyperbaric oxygen treatment. Aim: This study evaluated the ow rate of the Baxter elastomeric LV10 Infusor™ pump under normobaric (101.3 kPa and three hyperbaric conditions of 203 kPa, 243 kPa and 284 kPa. Methods: Elastomeric pumps were secured to participants in the same manner as for a typical patient, except that a container collected the delivered antibiotic solution. Pumps and tubing were weighed before and after the test period to determine volume delivered and to calculate ow rates at sea level and the three commonly used hyperbaric treatment pressures at two different time periods, 0-2 hours (h) and 19-21 h into the infusion. Results: The mean ow rates in ml h-1 (SD) were: 9.5 (0.4), 10.3 (0.6), 10.4 (0.6), 10.4 (0.5) at 0-2 h and 10.5 (1.0), 12.2 (0.6), 9.4 (0.5), 10.3 (0.9) at 19-21 h for the normobaric, 203 kPa, 243 kPa and 284 kPa conditions respectively. There was no signi cant association between ow rate and time period (P = 0.166) but the 203 kPa ow rates were signi cantly faster than the other ow rates (P = 0.008). In retrospect, the 203 kPa experiments had all been conducted with the same antibiotic solution (ceftazidime 6 g). Repeating that experimental arm using ucloxacillin 8 g produced ow rates of 10.4 (0.8) ml h-1, with no signi cant associations between ow rate and time period (P = 0.652) or pressure (P = 0.705). Conclusion: In this study, the ow rate of the Baxter LV10 Infusor™ device was not signicantly affected by increases in ambient pressure across the pressure range of 101.3 kPa to 284 kPa, and ow rates were generally within a clinically acceptable range of 9-12 ml h-1. However, there was evidence that the speci c antibiotic solution might affect ow rates and this requires further study.

LanguageEnglish (US)
JournalDiving and Hyperbaric Medicine
Volume47
Issue number1
StatePublished - 2017

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Infusion Pumps
Pressure
elastomeric
Anti-Bacterial Agents
Therapeutics
Ceftazidime
Oceans and Seas
Oxygen
Equipment and Supplies

Keywords

  • Drugs
  • Equipment
  • Flow rate
  • Hyperbaric oxygen therapy
  • Infectious diseases
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

Cite this

An assessment of the performance of the baxter elastomeric (LV10) infusor™ pump under hyperbaric conditions. / Perks, Stephen; Blake, Denise F.; Young, Derelle A.; Hardman, John; Brown, Lawrence H.; Lewis, Iestyn; Pain, Tilley.

In: Diving and Hyperbaric Medicine, Vol. 47, No. 1, 2017.

Research output: Research - peer-reviewArticle

Perks, Stephen ; Blake, Denise F. ; Young, Derelle A. ; Hardman, John ; Brown, Lawrence H. ; Lewis, Iestyn ; Pain, Tilley. / An assessment of the performance of the baxter elastomeric (LV10) infusor™ pump under hyperbaric conditions. In: Diving and Hyperbaric Medicine. 2017 ; Vol. 47, No. 1.
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abstract = "Introduction: There are limited data on the use of elastomeric infusion pumps during hyperbaric oxygen treatment. Aim: This study evaluated the ow rate of the Baxter elastomeric LV10 Infusor™ pump under normobaric (101.3 kPa and three hyperbaric conditions of 203 kPa, 243 kPa and 284 kPa. Methods: Elastomeric pumps were secured to participants in the same manner as for a typical patient, except that a container collected the delivered antibiotic solution. Pumps and tubing were weighed before and after the test period to determine volume delivered and to calculate ow rates at sea level and the three commonly used hyperbaric treatment pressures at two different time periods, 0-2 hours (h) and 19-21 h into the infusion. Results: The mean ow rates in ml h-1 (SD) were: 9.5 (0.4), 10.3 (0.6), 10.4 (0.6), 10.4 (0.5) at 0-2 h and 10.5 (1.0), 12.2 (0.6), 9.4 (0.5), 10.3 (0.9) at 19-21 h for the normobaric, 203 kPa, 243 kPa and 284 kPa conditions respectively. There was no signi cant association between ow rate and time period (P = 0.166) but the 203 kPa ow rates were signi cantly faster than the other ow rates (P = 0.008). In retrospect, the 203 kPa experiments had all been conducted with the same antibiotic solution (ceftazidime 6 g). Repeating that experimental arm using ucloxacillin 8 g produced ow rates of 10.4 (0.8) ml h-1, with no signi cant associations between ow rate and time period (P = 0.652) or pressure (P = 0.705). Conclusion: In this study, the ow rate of the Baxter LV10 Infusor™ device was not signicantly affected by increases in ambient pressure across the pressure range of 101.3 kPa to 284 kPa, and ow rates were generally within a clinically acceptable range of 9-12 ml h-1. However, there was evidence that the speci c antibiotic solution might affect ow rates and this requires further study.",
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T1 - An assessment of the performance of the baxter elastomeric (LV10) infusor™ pump under hyperbaric conditions

AU - Perks,Stephen

AU - Blake,Denise F.

AU - Young,Derelle A.

AU - Hardman,John

AU - Brown,Lawrence H.

AU - Lewis,Iestyn

AU - Pain,Tilley

PY - 2017

Y1 - 2017

N2 - Introduction: There are limited data on the use of elastomeric infusion pumps during hyperbaric oxygen treatment. Aim: This study evaluated the ow rate of the Baxter elastomeric LV10 Infusor™ pump under normobaric (101.3 kPa and three hyperbaric conditions of 203 kPa, 243 kPa and 284 kPa. Methods: Elastomeric pumps were secured to participants in the same manner as for a typical patient, except that a container collected the delivered antibiotic solution. Pumps and tubing were weighed before and after the test period to determine volume delivered and to calculate ow rates at sea level and the three commonly used hyperbaric treatment pressures at two different time periods, 0-2 hours (h) and 19-21 h into the infusion. Results: The mean ow rates in ml h-1 (SD) were: 9.5 (0.4), 10.3 (0.6), 10.4 (0.6), 10.4 (0.5) at 0-2 h and 10.5 (1.0), 12.2 (0.6), 9.4 (0.5), 10.3 (0.9) at 19-21 h for the normobaric, 203 kPa, 243 kPa and 284 kPa conditions respectively. There was no signi cant association between ow rate and time period (P = 0.166) but the 203 kPa ow rates were signi cantly faster than the other ow rates (P = 0.008). In retrospect, the 203 kPa experiments had all been conducted with the same antibiotic solution (ceftazidime 6 g). Repeating that experimental arm using ucloxacillin 8 g produced ow rates of 10.4 (0.8) ml h-1, with no signi cant associations between ow rate and time period (P = 0.652) or pressure (P = 0.705). Conclusion: In this study, the ow rate of the Baxter LV10 Infusor™ device was not signicantly affected by increases in ambient pressure across the pressure range of 101.3 kPa to 284 kPa, and ow rates were generally within a clinically acceptable range of 9-12 ml h-1. However, there was evidence that the speci c antibiotic solution might affect ow rates and this requires further study.

AB - Introduction: There are limited data on the use of elastomeric infusion pumps during hyperbaric oxygen treatment. Aim: This study evaluated the ow rate of the Baxter elastomeric LV10 Infusor™ pump under normobaric (101.3 kPa and three hyperbaric conditions of 203 kPa, 243 kPa and 284 kPa. Methods: Elastomeric pumps were secured to participants in the same manner as for a typical patient, except that a container collected the delivered antibiotic solution. Pumps and tubing were weighed before and after the test period to determine volume delivered and to calculate ow rates at sea level and the three commonly used hyperbaric treatment pressures at two different time periods, 0-2 hours (h) and 19-21 h into the infusion. Results: The mean ow rates in ml h-1 (SD) were: 9.5 (0.4), 10.3 (0.6), 10.4 (0.6), 10.4 (0.5) at 0-2 h and 10.5 (1.0), 12.2 (0.6), 9.4 (0.5), 10.3 (0.9) at 19-21 h for the normobaric, 203 kPa, 243 kPa and 284 kPa conditions respectively. There was no signi cant association between ow rate and time period (P = 0.166) but the 203 kPa ow rates were signi cantly faster than the other ow rates (P = 0.008). In retrospect, the 203 kPa experiments had all been conducted with the same antibiotic solution (ceftazidime 6 g). Repeating that experimental arm using ucloxacillin 8 g produced ow rates of 10.4 (0.8) ml h-1, with no signi cant associations between ow rate and time period (P = 0.652) or pressure (P = 0.705). Conclusion: In this study, the ow rate of the Baxter LV10 Infusor™ device was not signicantly affected by increases in ambient pressure across the pressure range of 101.3 kPa to 284 kPa, and ow rates were generally within a clinically acceptable range of 9-12 ml h-1. However, there was evidence that the speci c antibiotic solution might affect ow rates and this requires further study.

KW - Drugs

KW - Equipment

KW - Flow rate

KW - Hyperbaric oxygen therapy

KW - Infectious diseases

KW - Treatment

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