Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study

Kara M. Whitaker, Kelley Pettee-Gabriel, Matthew P. Buman, Mark A. Pereira, David R. Jacobs, Jared P. Reis, Bethany Barone Gibbs, Mercedes R. Carnethon, John Staudenmayer, Stephen Sidney, Barbara Sternfeld

Research output: Contribution to journalArticle

Abstract

Background-—Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results-—Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score ( 0.01 SD [95% CI, 0.02, 0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, 0.27, 0.02]), insulin (0.20 lU/mL [95% CI, 0.35, 0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score ( 0.08 [95% CI, 0.13, 0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, 2.21, 0.84]), insulin ( 1.13 lU/mL [95% CI, 1.95, 0.31]), triglycerides ( 6.92 mg/dL [95% CI, 11.69, 2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions-—Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

LanguageEnglish (US)
Article numbere010212
JournalJournal of the American Heart Association
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2019

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Young Adult
Coronary Vessels
Epidemiology
Exercise
Waist Circumference
HDL Cholesterol
Light
Insulin
Triglycerides
Lipoprotein(a)
Health
Blood Glucose
Linear Models
Cross-Sectional Studies
Blood Pressure

Keywords

  • Cardiometabolic risk
  • Epidemiology
  • Isotemporal substitution
  • Physical activity
  • Sedentary time

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors : The CARDIA study. / Whitaker, Kara M.; Pettee-Gabriel, Kelley; Buman, Matthew P.; Pereira, Mark A.; Jacobs, David R.; Reis, Jared P.; Gibbs, Bethany Barone; Carnethon, Mercedes R.; Staudenmayer, John; Sidney, Stephen; Sternfeld, Barbara.

In: Journal of the American Heart Association, Vol. 8, No. 1, e010212, 01.01.2019.

Research output: Contribution to journalArticle

Whitaker, KM, Pettee-Gabriel, K, Buman, MP, Pereira, MA, Jacobs, DR, Reis, JP, Gibbs, BB, Carnethon, MR, Staudenmayer, J, Sidney, S & Sternfeld, B 2019, 'Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors: The CARDIA study', Journal of the American Heart Association, vol. 8, no. 1, e010212. https://doi.org/10.1161/JAHA.118.010212
Whitaker, Kara M. ; Pettee-Gabriel, Kelley ; Buman, Matthew P. ; Pereira, Mark A. ; Jacobs, David R. ; Reis, Jared P. ; Gibbs, Bethany Barone ; Carnethon, Mercedes R. ; Staudenmayer, John ; Sidney, Stephen ; Sternfeld, Barbara. / Associations of accelerometer-measured sedentary time and physical activity with prospectively assessed cardiometabolic risk factors : The CARDIA study. In: Journal of the American Heart Association. 2019 ; Vol. 8, No. 1.
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abstract = "Background-—Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results-—Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score ( 0.01 SD [95{\%} CI, 0.02, 0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95{\%} CI, 0.27, 0.02]), insulin (0.20 lU/mL [95{\%} CI, 0.35, 0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95{\%} CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score ( 0.08 [95{\%} CI, 0.13, 0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95{\%} CI, 2.21, 0.84]), insulin ( 1.13 lU/mL [95{\%} CI, 1.95, 0.31]), triglycerides ( 6.92 mg/dL [95{\%} CI, 11.69, 2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95{\%} CI, 0.45, 2.73]; all P<0.05). Conclusions-—Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.",
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AU - Pereira, Mark A.

AU - Jacobs, David R.

AU - Reis, Jared P.

AU - Gibbs, Bethany Barone

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N2 - Background-—Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results-—Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005–2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015–2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score ( 0.01 SD [95% CI, 0.02, 0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, 0.27, 0.02]), insulin (0.20 lU/mL [95% CI, 0.35, 0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score ( 0.08 [95% CI, 0.13, 0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, 2.21, 0.84]), insulin ( 1.13 lU/mL [95% CI, 1.95, 0.31]), triglycerides ( 6.92 mg/dL [95% CI, 11.69, 2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions-—Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

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KW - Epidemiology

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