Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy

Akshay Malhotra, Uttam Sharma, Shyamly Puhan, Naga Chandra Bandari, Anjali Kharb, P. P. Arifa, Lovlesh Thakur, Hridayesh Prakash, Karen Vasquez, Aklank Jain

Research output: Contribution to journalReview article

Abstract

The five-year survival rate of esophageal cancer patients is less than 20%. This may be due to increased resistance (acquired or intrinsic) of tumor cells to chemo/radiotherapies, often caused by aberrant cell cycle, deregulated apoptosis, increases in growth factor signaling pathways, and/or changes in the proteome network. In addition, deregulation in non-coding RNA-mediated signaling pathways may contribute to resistance to therapies. At the molecular level, these resistance factors have now been linked to various microRNA (miRNAs), which have recently been shown to control cell development, differentiation and neoplasia. The increased stability and dysregulated expression of miRNAs have been associated with increased resistance to various therapies in several cancers, including esophageal cancer. Therefore, miRNAs represent the next generation of molecules with tremendous potential as biomarkers and therapeutic targets. However, detailed studies on miRNA-based therapeutic interventions are still in their infancy. Hence, in this review, we have summarized the current status of microRNAs in dictating the resistance/sensitivity of tumor cells to chemotherapy and radiotherapy. In addition, we have discussed various strategies to increase radiosensitivity, including targeted therapy, and the use of miRNAs as radiosensitive/radioresistance biomarkers for esophageal cancer in the clinical setting.

LanguageEnglish (US)
Pages148-157
Number of pages10
JournalBiochimie
Volume156
DOIs
StatePublished - Jan 1 2019

Fingerprint

Esophageal Neoplasms
MicroRNAs
Stabilization
Cells
Biomarkers
Chemoradiotherapy
Tumors
Neoplasms
Radiotherapy
Therapeutics
Untranslated RNA
Chemotherapy
Deregulation
R Factors
Radiation Tolerance
Proteome
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Cell Cycle
Survival Rate

Keywords

  • Esophageal cancer
  • microRNAs
  • Radioresistance
  • Radiosenstivity
  • Tumor resistance

ASJC Scopus subject areas

  • Biochemistry

Cite this

Malhotra, A., Sharma, U., Puhan, S., Chandra Bandari, N., Kharb, A., Arifa, P. P., ... Jain, A. (2019). Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy. Biochimie, 156, 148-157. https://doi.org/10.1016/j.biochi.2018.10.006

Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy. / Malhotra, Akshay; Sharma, Uttam; Puhan, Shyamly; Chandra Bandari, Naga; Kharb, Anjali; Arifa, P. P.; Thakur, Lovlesh; Prakash, Hridayesh; Vasquez, Karen; Jain, Aklank.

In: Biochimie, Vol. 156, 01.01.2019, p. 148-157.

Research output: Contribution to journalReview article

Malhotra, A, Sharma, U, Puhan, S, Chandra Bandari, N, Kharb, A, Arifa, PP, Thakur, L, Prakash, H, Vasquez, K & Jain, A 2019, 'Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy' Biochimie, vol. 156, pp. 148-157. https://doi.org/10.1016/j.biochi.2018.10.006
Malhotra, Akshay ; Sharma, Uttam ; Puhan, Shyamly ; Chandra Bandari, Naga ; Kharb, Anjali ; Arifa, P. P. ; Thakur, Lovlesh ; Prakash, Hridayesh ; Vasquez, Karen ; Jain, Aklank. / Stabilization of miRNAs in esophageal cancer contributes to radioresistance and limits efficacy of therapy. In: Biochimie. 2019 ; Vol. 156. pp. 148-157.
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